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ex-i

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Skin booster

ex-i

A skin booster built around high-purity hyaluronic acid and PDRN, combined with growth-factor peptides carried by a cell-permeable delivery technology (MTD).

Composition

  • High-purity hyaluronic acid (3 MDa)
  • PDRN (polynucleotide, salmon-derived)
  • Botulinum-derived polypeptide
  • Growth-factor peptides (EGF, FGF2, IGF-1, PDGF-AA)
  • Pentapeptide-4, tranexamic acid, trehalose

Full product details, including usage guidance, are available on request.

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Why ex-i

Rapid onset

  • Immediate boosting effect after same-day treatment, due to the action of MTD botulinum.
  • Maximises the synergies of combined treatment procedures.

Optimal skin regeneration

  • Induces activation of VEGF-producing cells in the skin, from the polynucleotide (PN).
  • Promotes the growth of ECM factors, from the four growth factors with MTD.
  • Boosting effect on collagen synthesis after cosmetic treatment.

Restoring balance

  • High-purity 3 MDa hyaluronic acid and trehalose moisturise the skin outside and inside at the same time.
  • Increased skin soothing after cosmetic treatment.

Aseptic manufacturing

  • Produced in an aseptic environment, with no preservatives.

What it is formulated for

High-concentration ingredients for a lifting effect, with PN and five growth factors carried by MTD cell-penetration technology.

01Wrinkle improvementFrom the high-concentration botulinum-derived ingredient.
02Rejuvenation and elasticityRegeneration and skin elasticity from four growth factors with MTD technology, and PN (salmon DNA extract).
03Pore size and inflammationControls the skin's oil and water balance, and acts on pore size and inflammation.
04Minimal irritationNo preservatives, and manufacture in a sterile environment, to keep irritation to a minimum.

Ingredient features

Eleven active ingredients, presented here as the manufacturer's own ingredient breakdown. Each MTD ingredient pairs a functional protein with a carrier peptide.

High-purity hyaluronic acid

Sodium Hyaluronate

  • 3 MDa hyaluronic acid
  • Medical-grade high purity
  • Moisturising

PDRN

Sodium DNA

  • Salmon-extract DNA
  • Medical-grade high purity
  • Cell regeneration

Botulinum polypeptide

Methionyl r-Clostridium Botulinum Polypeptide-1, Hexapeptide-40

  • Acts in the dermis
  • Patent pending in 11 countries (7 registered)

MTD-EGF

sh-Oligopeptide-1, Nonapeptide-29

  • Skin-permeable epidermal growth factor
  • Cell regeneration

MTD-FGF2

sh-Polypeptide-1, Nonapeptide-29

  • Cell-permeable basic fibroblast growth factor
  • Cell regeneration

MTD-IGF1

Methionyl sh-Oligopeptide-2, Decapeptide-40

  • Cell-permeable insulin-like growth factor 1
  • Cell regeneration

MTD-PDGF AA

r-(Methionyl sh-Polypeptide-8, Decapeptide-40)

  • Cell-permeable platelet-derived growth factor AA
  • Cell regeneration

MTD Pentapeptide-4

Nonapeptide-29, Pentapeptide-4

  • Skin-permeable pentapeptide-4
  • Collagen-synthesis facilitator

Treatment areas

Applied in small amounts at regular intervals across the area being treated.

Under the eyes
Under the eyes
Neck
Neck
Cheeks and chin
Cheeks and chin
Back of hand
Back of hand
Forehead
Forehead

Ingredient science

The brochure documents each active ingredient with the manufacturer's own laboratory work. Diffusion multiples below compare the MTD-conjugated form against the same protein unconjugated, in an EpiDermFT Franz diffusion cell assay. They are the manufacturer's figures, not independent testing.

01

Botulinum polypeptide

Methionyl r-Clostridium Botulinum Polypeptide-1, Hexapeptide-40

  • Botulinum light chain type A fused to the MTD carrier protein: 469 amino acids, 53.6 kDa.
  • Cell-penetration and keratinocyte permeation observed in SiMa cells at 1 minute and 3 hours.
  • Patent pending in 11 countries, registered in 7.
02

Hyaluronic acid

Sodium Hyaluronate

  • Medical-grade high purity, 3 MDa.
  • Holds moisture in the skin.
03

PDRN

Sodium DNA

  • Polynucleotide from salmon extract, medical-grade high purity.
  • Induces activation of VEGF-producing cells.
04

MTD-EGF

sh-Oligopeptide-1, Nonapeptide-29

  • Skin-permeable epidermal growth factor.
  • Diffusion 16.25× against unconjugated EGF.
05

MTD-FGF2

sh-Polypeptide-1, Nonapeptide-29

  • Cell-permeable basic fibroblast growth factor.
  • Fibroblast growth observed over 72 hours in EpiDermFT tissue.
06

MTD-IGF1

Methionyl sh-Oligopeptide-2, Decapeptide-40

  • Cell-permeable insulin-like growth factor 1.
  • Diffusion 84.04× against unconjugated IGF-1.
07

MTD-PDGF AA

r-(Methionyl sh-Polypeptide-8, Decapeptide-40)

  • Cell-permeable platelet-derived growth factor AA.
  • Relative mean fluorescence intensity 5.1 against 1.0 for the unconjugated protein.
08

MTD-SOD1

sh-Polypeptide-11, Nonapeptide-29

  • Cell-permeable superoxide dismutase, an antioxidant enzyme.
  • Permeation 2.345-fold against the unconjugated enzyme.
09

MTD Pentapeptide-4

Nonapeptide-29, Pentapeptide-4

  • Skin-permeable pentapeptide-4, a collagen-synthesis facilitator.
  • Cumulative flux 834 against 26 for the unconjugated peptide, a 32-fold difference.
10

MTD Acetyl Hexapeptide

Nonapeptide-29, Acetyl Hexapeptide-8

  • A peptide with a botulinum-like mechanism, used for expression lines.
  • 23× more permeable in the diffusion assay, 4× by fluorescence measurement.
11

Tranexamic acid and trehalose

Tranexamic Acid, Trehalose

  • Tranexamic acid is a KFDA-listed functional brightening ingredient.
  • Trehalose is the formulation's moisturising agent.
Botulinum polypeptide structure
Botulinum polypeptide structureLight chain type A fused to the MTD carrier protein.
Cell penetration, SiMa cells
Cell penetration, SiMa cellsObserved at 1 minute and 3 hours, with keratinocyte permeation alongside.
EGF diffusion fold
EGF diffusion foldEpiDermFT Franz diffusion cell assay: 1.00 for EGF, 16.25 for the MTD-conjugated form.
EGF confocal observation
EGF confocal observationEpiDermFT confocal microscopy at ×200: DAPI, Nomarski, FITC and merged.
IGF-1 confocal observation
IGF-1 confocal observationSame assay, comparing IGF-1 with the MTD-conjugated form.
PDGF-AA confocal observation
PDGF-AA confocal observationSame assay, comparing PDGF-AA with the MTD-conjugated form.
SOD1 confocal observation
SOD1 confocal observationSame assay, comparing SOD1 with the MTD-conjugated form.
Acetyl hexapeptide permeability
Acetyl hexapeptide permeabilitySame assay, comparing acetyl hexapeptide with the MTD-conjugated form.